Nanopublications

Matches in Nanopublications for { ?s ?p ?o <http://purl.org/np/RAYOsXf6wLjW5R7f7Sjg4bjbYzKnxF5hS7EPHa73sCnP4#assertion>. }

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ameliorates label "ameliorates - A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure, clinical intervention) and a condition (a phenotype or disease), where the presence of the entity reduces or eliminates some or all aspects of the condition." assertion.
treats label "treats - holds between a therapeutic procedure or chemical entity and a disease or phenotypic feature that it is used to treat" assertion.
associated_with_decreased_likelihood_of label "associated with decreased likelihood of - Expresses a relationship between two named things where the relationship is typically generated statistically and the state or fact of something is less probable." assertion.
enabled_by label "enabled by - holds between a process and a physical entity, where the physical entity executes the process" assertion.
predisposes label "predisposes - holds between two entities where exposure to one entity increases the chance of developing the other" assertion.
location_of label "location of - holds between material entity or site and a material entity that is located within it (but not considered a part of it)" assertion.
is_splice_site_variant_of label "is splice site variant of - holds between a sequence variant and a gene, such the sequence variant is in the canonical splice site of one of the gene's exons." assertion.
affects_risk_for label "affects risk for - holds between two entities where exposure to one entity alters the chance of developing the other" assertion.
has_sequence_location label "has sequence location - holds between two nucleic acid entities when the subject can be localized in sequence coordinates on the object. For example, between an exon and a chromosome/contig." assertion.
causes label "causes - holds between two entities where the occurrence, existence, or activity of one causes the occurrence or generation of the other" assertion.
has_not_completed label "has not completed - holds between an entity and a process that the entity is capable of, but has not completed" assertion.
homologous_to label "homologous to - holds between two biological entities that have common evolutionary origin" assertion.
physically_interacts_with label "physically interacts with - holds between two entities that make physical contact as part of some interaction. does not imply a causal relationship." assertion.
preceded_by label "preceded by - holds between two processes, where the other is completed before the one begins" assertion.
mentioned_by label "mentioned by - refers to is a relation between one named thing and the information content entity that it makes reference to." assertion.
coexpressed_with label "coexpressed with - holds between any two genes or gene products, in which both are generally expressed within a single defined experimental context." assertion.
has_nutrient label "has nutrient - one or more nutrients which are growth factors for a living organism" assertion.
is_non_coding_variant_of label "is non coding variant of - holds between a sequence variant and a gene, where the variant does not affect the coding sequence" assertion.
enables label "enables - holds between a physical entity and a process, where the physical entity executes the process" assertion.
has_variant_part label "has variant part - holds between a nucleic acid entity and a nucleic acid entity that is a sub-component of it" assertion.
genetic_neighborhood_of label "genetic neighborhood of - holds between two genes located nearby one another on a chromosome. " assertion.
regulates label "regulates - A more specific form of affects, that implies the effect results from a biologically evolved control mechanism. Gene-affects-gene relationships will (almost) always involve regulation. Exogenous/environmental chemical-affects-gene relationships are not cases of regulation in this definition. Instead these would be captured using the 'affects' predicate, or possibly one of the 'interacts with' predicates depending on the nature of the interaction." assertion.
disrupted_by label "disrupted by - describes a relationship where the structure, function, or occurrence of one entity is degraded or interfered with by another." assertion.
is_synonymous_variant_of label "is synonymous variant of - holds between a sequence variant and a gene, such the sequence variant is in the coding sequence of the gene, but results in the same amino acid sequence" assertion.
gene_associated_with_condition label "gene associated with condition - holds between a gene and a disease or phenotypic feature that the gene or its alleles/products may influence, contribute to, or correlate with" assertion.
positively_correlated_with label "positively correlated with - A relationship that holds between two concepts represented by variables for which a statistical correlation is demonstrated, wherein variable values move together in the same direction (i.e. increased in one or presence of one correlates with an increase or presence of the other)." assertion.
has_excipient label "has excipient - holds between a drug and a molecular entities in which the latter is a part of the former, and is a biologically inactive component" assertion.
member_of label "member of - Defines a mereological relation between a item and a collection." assertion.
model_of label "model of - holds between a thing and some other thing it approximates for purposes of scientific study, in virtue of its exhibiting similar features of the studied entity." assertion.
in_cell_population_with label "in cell population with - holds between two genes or gene products that are expressed in the same cell type or population" assertion.
is_excipient_of label "is excipient of - holds between a molecular entity and a drug in which the former is a part of the latter, and is a biologically inactive component" assertion.
mentions label "mentions - refers to is a relation between one information content entity and the named thing that it makes reference to." assertion.
in_pathway_with label "in pathway with - holds between two genes or gene products that are part of in the same biological pathway" assertion.
is_nonsense_variant_of label "is nonsense variant of - holds between a sequence variant and a gene, such the sequence variant results in a premature stop codon" assertion.
has_food_component label "has food component - holds between food and one or more chemical entities composing it, irrespective of nutritional value (i.e. could also be a contaminant or additive)" assertion.
has_gene_product label "has gene product - holds between a gene and a transcribed and/or translated product generated from it" assertion.
produces label "produces - holds between a material entity and a product that is generated through the intentional actions or functioning of the material entity" assertion.
opposite_of label "opposite of - x is the opposite of y if there exists some distance metric M, and there exists no z such as M(x,z) <= M(x,y) or M(y,z) <= M(y,x). (This description is from RO. Needs to be rephrased)." assertion.
capable_of label "capable of - holds between a physical entity and process or function, where the continuant alone has the ability to carry out the process or function." assertion.
associated_with_likelihood_of label "associated with likelihood of - A a relationship that holds between two concepts represented by variables for which a statistical dependence is demonstrated, wherein the state or value of one variable predicts the future state or value of the other. E.g. the statement “An Atrial Fibrillation (Afib) diagnosis is associated with likelihood of a Myocardial Infarction (MI) diagnosis” asserts that the state of having Afib is associated with an increased or decreased likelihood that a patient will later exhibit MI." assertion.
affected_by label "affected by - describes an entity of which the state or quality is affected by another existing entity." assertion.
colocalizes_with label "colocalizes with - holds between two entities that are observed to be located in the same place." assertion.
derives_into label "derives into - holds between two distinct material entities, the old entity and the new entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity" assertion.
affects label "affects - describes an entity that has a direct affect on the state or quality of another existing entity. Use of the 'affects' predicate implies that the affected entity already exists, unlike predicates such as 'affects risk for' and 'prevents, where the outcome is something that may or may not come to be." assertion.
assesses label "assesses - The effect of a thing on a target was interrogated in some assay. A relationship between some perturbing agent (usually a chemical compound) and some target entity, where the affect of the perturbing agent on the target entity was interrogated in a particular assay. The target might be a particular protein, tissue, phenotype, whole organism, cell line, or other type of biological entity." assertion.
target_for label "target for - A gene is a target of a disease when its products are druggable and when a drug interaction with the gene product could have a therapeutic effect" assertion.
related_to label "related to - A relationship that is asserted between two named things" assertion.
nutrient_of label "nutrient of - holds between a one or more chemical entities present in food, irrespective of nutritional value (i.e. could also be a contaminant or additive)" assertion.
expressed_in label "expressed in - holds between a gene or gene product and an anatomical entity in which it is expressed" assertion.
directly_physically_interacts_with label "directly physically interacts with - A causal mechanism mediated by a direct contact between the effector and target entities (this contact may be weak or strong, transient or stable)." assertion.
has_active_ingredient label "has active ingredient - holds between a drug and a molecular entity in which the latter is a part of the former, and is a biologically active component" assertion.
has_metabolite label "has metabolite - holds between two molecular entities in which the second one is derived from the first one as a product of metabolism" assertion.
gene_product_of label "gene product of - definition x has gene product of y if and only if y is a gene (SO:0000704) that participates in some gene expression process (GO:0010467) where the output of thatf process is either y or something that is ribosomally translated from x" assertion.
decreased_likelihood_associated_with label "decreased likelihood associated with - " assertion.
has_mode_of_inheritance label "has mode of inheritance - Relates a disease or phenotypic feature to its observed genetic segregation and assumed associated underlying DNA manifestation (i.e. autosomal, sex or mitochondrial chromosome)." assertion.
increased_likelihood_associated_with label "increased likelihood associated with - " assertion.
located_in label "located in - holds between a material entity and a material entity or site within which it is located (but of which it is not considered a part)" assertion.
likelihood_associated_with label "likelihood associated with - " assertion.
increases_amount_or_activity_of label "increases amount or activity of - A grouping mixin to help with searching for all the predicates that increase the amount or activity of the object." assertion.
has_molecular_consequence label "has molecular consequence - connects a sequence variant to a class describing the molecular consequence. E.g. SO:0001583" assertion.
food_component_of label "food component of - holds between a one or more chemical entities present in food, irrespective of nutritional value (i.e. could also be a contaminant or additive)" assertion.
transcribed_to label "transcribed to - inverse of transcribed from" assertion.
translation_of label "translation of - inverse of translates to" assertion.
response_affected_by label "response affected by - holds between two chemical entities where the susceptibility of a biological entity or system (e.g. an organism, cell, cellular component, macromolecular machine mixin, biological or pathological process) of one is affected by the action of the other." assertion.
decreases_response_to label "decreases response to - holds between two chemical entities where the action or effect of one decreases the susceptibility of a biological entity or system (e.g. an organism, cell, cellular component, macromolecular machine mixin, biological or pathological process) to the other" assertion.
transcribed_from label "transcribed from - x is transcribed from y if and only if x is synthesized from template y" assertion.
molecular_activity_has_output label "molecular activity has output - A chemical entity that is the output for the reaction" assertion.
is_metabolite_of label "is metabolite of - holds between two molecular entities in which the first one is derived from the second one as a product of metabolism" assertion.
has_input label "has input - holds between a process and a continuant, where the continuant is an input into the process" assertion.
genetically_interacts_with label "genetically interacts with - holds between two genes whose phenotypic effects are dependent on each other in some way - such that their combined phenotypic effects are the result of some interaction between the activity of their gene products. Examples include epistasis and synthetic lethality." assertion.
contraindicated_for label "contraindicated for - Holds between a drug and a disease or phenotype, such that a person with that disease should not be treated with the drug." assertion.
similar_to label "similar to - holds between an entity and some other entity with similar features." assertion.
gene_fusion_with label "gene fusion with - holds between two independent genes that have fused through translocation, interstitial deletion, or chromosomal inversion to form a new, hybrid gene. Fusion genes are often implicated in various neoplasms and cancers." assertion.
biomarker_for label "biomarker for - holds between a measurable chemical entity and a disease or phenotypic feature, where the entity is used as an indicator of the presence or state of the disease or feature." assertion.
paralogous_to label "paralogous to - a homology relationship that holds between entities (typically genes) that diverged after a duplication event." assertion.
diagnoses label "diagnoses - a relationship that identifies the nature of (an illness or other problem) by examination of the symptoms." assertion.
temporally_related_to label "temporally related to - holds between two entities with a temporal relationship" assertion.
precedes label "precedes - holds between two processes, where one completes before the other begins" assertion.
is_active_ingredient_of label "is active ingredient of - holds between a molecular entity and a drug, in which the former is a part of the latter, and is a biologically active component" assertion.
associated_with_sensitivity_to label "associated with sensitivity to - A relation that holds between a named thing and a chemical that specifies that the change in the named thing is found to be associated with the degree of sensitivity to treatment by the chemical." assertion.
derives_from label "derives from - holds between two distinct material entities, the new entity and the old entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity" assertion.
translates_to label "translates to - x (amino acid chain/polypeptide) is the ribosomal translation of y (transcript) if and only if a ribosome reads y (transcript) through a series of triplet codon-amino acid adaptor activities (GO:0030533) and produces x (amino acid chain/polypeptide)" assertion.
expresses label "expresses - holds between an anatomical entity and gene or gene product that is expressed there" assertion.
is_frameshift_variant_of label "is frameshift variant of - holds between a sequence variant and a gene, such the sequence variant causes a disruption of the translational reading frame, because the number of nucleotides inserted or deleted is not a multiple of three." assertion.
binds label "binds - A causal mechanism mediated by the direct contact between effector and target chemical or biomolecular entity, which form a stable physical interaction." assertion.
prevented_by label "prevented by - holds between a potential outcome of which the likelihood was reduced by the application or use of an entity." assertion.
occurs_together_in_literature_with label "occurs together in literature with - holds between two entities where their co-occurrence is correlated by counts of publications in which both occur, using some threshold of occurrence as defined by the edge provider." assertion.
disease_has_location label "disease has location - A relationship between a disease and an anatomical entity where the disease has one or more features that are located in that entity." assertion.
xenologous_to label "xenologous to - a homology relationship characterized by an interspecies (horizontal) transfer since the common ancestor." assertion.
has_output label "has output - holds between a process and a continuant, where the continuant is an output of the process" assertion.
associated_with_resistance_to label "associated with resistance to - A relation that holds between a named thing and a chemical that specifies that the change in the named thing is found to be associated with the degree of resistance to treatment by the chemical." assertion.
has_phenotype label "has phenotype - holds between a biological entity and a phenotype, where a phenotype is construed broadly as any kind of quality of an organism part, a collection of these qualities, or a change in quality or qualities (e.g. abnormally increased temperature). In SNOMEDCT, disorders with keyword 'characterized by' should translate into this predicate." assertion.
participates_in label "participates in - holds between a continuant and a process, where the continuant is somehow involved in the process" assertion.
coexists_with label "coexists with - holds between two entities that are co-located in the same aggregate object, process, or spatio-temporal region" assertion.
part_of label "part of - holds between parts and wholes (material entities or processes)" assertion.
orthologous_to label "orthologous to - a homology relationship between entities (typically genes) that diverged after a speciation event." assertion.
has_adverse_event label "has adverse event - An untoward medical occurrence in a patient or clinical investigation subject that happens during treatment with a therapeutic agent. Adverse events may be caused by something other than the drug or therapy being given and may include abnormal laboratory finding, symptoms, or diseases temporally associated with the treatment, whether or not considered related to the treatment. Adverse events are unintended effects that occur when a medication is administered correctly." assertion.
has_member label "has member - Defines a mereological relation between a collection and an item." assertion.
occurs_in label "occurs in - holds between a process and a material entity or site within which the process occurs" assertion.
genetic_association label "genetic association - Co-occurrence of a certain allele of a genetic marker and the phenotype of interest in the same individuals at above-chance level" assertion.