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[Other members of the SMAD family are excellent candidates for JPS, especially SMAD2 (which, like SMAD4, is mutated somatically in colorectal cancers), SMAD3 (which causes colorectal cancer when 'knocked out' in mice), SMAD5, and SMAD1.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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