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[We attempted replication of the top meta-analysis single nucleotide polymorphisms for these genes in the Global BPgen Consortium (n=34,433) and the Women's Genome Health Study (n=23,019) and found significant results for rs1801253 in ADRB1 (Arg389Gly), with the Gly allele associated with a lower mean systolic blood pressure (?: 0.57 mm Hg; SE: 0.09 mm Hg; meta-analysis: P=4.7�10(-10)), diastolic blood pressure (?: 0.36 mm Hg; SE: 0.06 mm Hg; meta-analysis: P=9.5�10(-10)), and prevalence of hypertension (?: 0.06 mm Hg; SE: 0.02 mm Hg; meta-analysis: P=3.3�10(-4)).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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