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[Here we show that down-regulation of the class II PI3K isoform PI3K-C2? specifically impairs insulin granule exocytosis in rat insulinoma cells without affecting insulin content, the number of insulin granules at the plasma membrane, or the expression levels of key proteins involved in insulin secretion.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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