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[This review addresses the gaps in knowledge in ER? research as it pertains to BCa regarding the following questions: (1) is ER? a tumor suppressor in BCa?; (2) do ER? isoforms play differential roles in breast carcinogenesis?; (3) do nuclear signaling and extranuclear ER? signaling differ in BCa?; (4) what are the consequences of post-translational modifications of ER? in BCa?; (5) how do co-regulators and interacting proteins increase functional diversity of ER??; and (6) how do the types of ligand and regulatory cis-elements affect the action of ER? in BCa?.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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